Wet granulation in laboratory-scale high shear mixers: Effect of chopper presence, design and impeller speed

Scale-up studies on high shear wet granulation process from mini-scale to commercial scale.

A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...

Effect of operating conditions and physico–chemical properties on the wet granulation kinetics in high shear mixer

Effect of impeller speed on properties of quiescent zone and entrainment in mechanical flotation cells

Flotation process in mechanical cells is carried out in highly turbulent conditions. In this work, the impact of impeller speed on four characteristics of the quiescent zone, i.e. zone height, turbulence, solid percentage, and gas holdup, and their relationship with the entrainment is investigated, and it is shown why at a higher impeller speed, entrainment is not significant. The height of the...

Wet Granulation: End-Point Determination and Scale-Up

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Impeller and volute design and optimization of the centrifugal pump with low specific speed in order to extract performance curves

Now a day centrifugal pumps are vital components of industries. Certainly, one of the most important specifications of centrifugal pumps are the performance curves. In the present work, performance curves of a centrifugal pumps are obtained by Computational fluid dynamics (CFD) and as an outcome, CFD results compare by practical curves. At the first step impeller and volute are designed with tw...